Related Experiment Video
Updated: Aug 7, 2025
10:23
Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
Published on: December 1, 2017
17.0K
Microbiome in urological diseases: Axis crosstalk and bladder disorders
Hae Woong Choi1, Kwang Woo Lee2, Young Ho Kim3
1Division of Life Sciences, Korea University, Seoul, Korea.
Investigative and Clinical Urology
|March 7, 2023
Summary
The human urinary microbiome is linked to urinary diseases, influenced by gut, vaginal, kidney, and bladder microbiota. Disruptions in these microbial communities can lead to urinary disease development.
Area of Science:
- Microbiology
- Urology
- Immunology
Background:
- The human urinary microbiome's role in urinary diseases is increasingly recognized.
- Interactions between urinary microbiota and other organ systems (gastrointestinal, vaginal, kidney, bladder) are crucial.
- These interactions involve complex bidirectional communication along the bladder-centered axis, impacting immune, metabolic, and nervous systems.
Purpose of the Study:
- To review the intricate relationships between microbial communities in various organs and urinary diseases.
- To highlight how disruptions in microbiota contribute to the development and progression of urinary diseases.
Main Methods:
- Literature review of studies on the human urinary microbiome and its associations with urinary diseases.
- Analysis of research detailing interconnections between urinary microbiota and other organ-specific microbiota.
- Examination of evidence on the bladder-centered axis and its role in disease pathogenesis.
Main Results:
- Urinary diseases are associated with alterations in the urinary microbiome.
- Microbiota from other organs, including the gastrointestinal tract, vagina, kidneys, and bladder, significantly influence urinary health.
- Disruptions in these interconnected microbial communities are implicated in the emergence and advancement of urinary diseases.
Conclusions:
- The urinary microbiome is a key factor in urinary disease development.
- Inter-organ microbial communication and its disruption are critical in understanding and potentially treating urinary diseases.
- Further research into these complex microbial interactions is warranted for therapeutic strategies.
More Related Videos
Related Concept Videos
01:25Urinary Tract Infection II: Pathophysiology
24
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
24
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
157
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
157
01:23Urinary Bladder
1.1K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.1K
01:26Urinary Tract Infection I: Introduction
30
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
30
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
19
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
19
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
23
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
23