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Updated: Aug 7, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
A hidden problem: peripheral artery disease in women
Mary M Kavurma1, Lauren Boccanfuso1, Carina Cutmore2,3
1Heart Research Institute, The University of Sydney, Sydney, NSW, Australia.
Peripheral artery disease (PAD) affects women disproportionately, with higher prevalence and worse outcomes. Addressing gender inequalities requires understanding complex biological, clinical, and societal factors in PAD care.
Area of Science:
- Cardiovascular Medicine
- Public Health
- Sociology of Health
Background:
- Peripheral artery disease (PAD) presents a significant global health burden, with emerging evidence indicating equal or greater prevalence in women.
- Women with PAD experience poorer clinical outcomes compared to men, yet the reasons for this disparity remain unclear.
Approach:
- A scoping review was performed using the World Health Organization model to analyze gender-related healthcare needs in PAD.
- The review examined biological, clinical, and societal factors contributing to gender inequalities in PAD diagnosis, treatment, and management.
Key Points:
- Identified multi-level complexities influencing gender-related inequities in PAD.
- Highlighted significant gaps in current knowledge regarding sex differences in PAD.
- Explored a social constructive perspective to understand gender disparities in PAD.
Conclusions:
- Addressing gender inequalities in PAD necessitates a comprehensive strategy that considers interacting biological, clinical, and societal variables.
- Future research should focus on filling identified knowledge gaps to improve healthcare for women with PAD.
- Strategies to improve gender-related needs in PAD healthcare must acknowledge and address multi-level complexities.
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