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Updated: Aug 7, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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High-Sensitivity Cardiac Troponin Algorithms and the Value of Likelihood Ratios

Brett G Fischer1, Arthur T Evans2

  • 1Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA. brf9036@med.cornell.edu.

Journal of General Internal Medicine
|March 7, 2023
PubMed

Insights

Likelihood ratios, not predictive values, improve interpretation of high-sensitivity cardiac troponin (hs-cTn) tests for myocardial infarction diagnosis. This study provides a method to calculate likelihood ratios for better patient-centered decision-making.

Area of Science:

  • Biomarker analysis
  • Diagnostic accuracy
  • Clinical decision-making

Background:

  • High-sensitivity cardiac troponin (hs-cTn) assays are standard for non-ST-elevation myocardial infarction diagnosis.
  • Current interpretation of hs-cTn results relies on predictive values, which have limited patient applicability.
  • Assay-specific interpretation guidelines for hs-cTn vary, complicating clinical use.

Keywords:
Clinical decision-makingDiagnosisEvidence-based practiceLikelihood ratioNon-ST elevated myocardial infarctionTroponin

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