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Updated: Aug 7, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Chemo- and Enantioselective Reduction of α-Keto Amides to α-Hydroxy Amides using Reusable CuO-Nanoparticles as
Gollapalli Narasimha Rao1, Govindasamy Sekar1
1Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
Abstract:
An efficient, commercially available, and reusable copper-oxide nanoparticle (CuO-NPs) and (R)-(-)-DTBM SEGPHOS catalyzed chemo- and enantioselective reduction of α-keto amides to α-hydroxy amides has been developed. The scope of the reaction has been studied with various α-keto amides containing electron-donating and electron-withdrawing groups affording the enantiomerically enriched α-hydroxy amides in good yields with excellent enantioselectivity. The CuO-NPs catalyst has been recovered and reused up to four catalytic cycles without any significant change in particle size, reactivity, and enantioselectivity.
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