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A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
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High Dose Inhalation with Gaseous Nitric Oxide in COVID-19 Treatment
E V Pechyonkin1, A V Kovrizhkin2, A V Pekshev3
1Stavropol State Medical University, 355017 Stavropol, Russia.
Biophysics
|March 8, 2023
Summary
High-dose inhalation of gaseous nitric oxide (NO) effectively treats COVID-19 in patients on high flow oxygenation. This novel method shows high efficiency by blocking SARS-CoV-2 replication through dinitrosyl iron complexes.
Area of Science:
- Medical research
- Infectious diseases
- Pulmonology
Background:
- COVID-19 poses a significant global health challenge, particularly for patients requiring respiratory support.
- High flow oxygenation is a common treatment for severe COVID-19, but effective antiviral therapies are crucial.
Purpose of the Study:
- To propose and implement a novel treatment method for COVID-19 using high-dose gaseous nitric oxide (NO).
- To evaluate the efficacy of inhaled NO in patients undergoing high flow oxygenation.
- To elucidate the potential mechanism of NO's antiviral action against SARS-CoV-2.
Main Methods:
- A treatment protocol involving high-dose inhalation of gaseous nitric oxide (NO) during spontaneous breathing was developed and applied.
- The method was implemented in patients with COVID-19 receiving high flow oxygenation.
- The study discusses the proposed mechanism involving dinitrosyl iron complexes.
Main Results:
- The proposed method demonstrated high efficiency in treating COVID-19 patients.
- Inhaled NO treatment showed significant positive outcomes in patients undergoing high flow oxygenation.
- A potential mechanism involving dinitrosyl iron complexes and their cytotoxic effect on SARS-CoV-2 was identified.
Conclusions:
- High-dose inhaled nitric oxide (NO) is an effective treatment for COVID-19 in patients on high flow oxygenation.
- The formation of dinitrosyl iron complexes in the respiratory tract may be responsible for blocking SARS-CoV-2 replication.
- This NO-based therapy offers a promising new approach for managing severe COVID-19.
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