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The Role of Bone Morphogenetic Protein 4 in Lung Diseases
Xiaoxiao Dong1, Yimin Mao2, Pengfei Gao2
1Department of Medicine, Clinical Medical College & the First Affiliated Hospital of Henan, University of Science and Technology, Luoyang 471003, China.
Abstract:
Bone morphogenetic protein 4 (BMP4) is a multifunctional secretory protein that belongs to the transforming growth factor β superfamily. BMPs transduce their signaling to the cytoplasm by binding to membrane receptors of the serine/threonine kinase family, including BMP type I and type II receptors. BMP4 participates in various biological processes, such as embryonic development, epithelial-mesenchymal transition, and maintenance of tissue homeostasis. The interaction between BMP4 and the corresponding endogenous antagonists plays a key role in the precise regulation of BMP4 signaling. In this paper, we review the pathogenesis of BMP4-related lung diseases and the foundation on which BMP4 endogenous antagonists have been developed as potential targets.
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