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Updated: Aug 7, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Arterial stiffness and blood pressure in treated hypertension: a longitudinal study

Shouling Wu1, Xue Tian2,3,4,5, Shuohua Chen1

  • 1Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan.

Journal of Hypertension
|March 8, 2023
PubMed

Insights

In patients with treated hypertension, reduced arterial stiffness significantly predicted lower blood pressure (BP). This suggests that improving arterial wall elasticity may be a key factor in lowering BP during antihypertensive treatment.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Vascular Biology

Background:

  • Arterial stiffness is known to increase before blood pressure (BP) rises in the general population.
  • The causal relationship between arterial stiffness and BP reduction during antihypertensive therapy remains unclear.
  • Understanding this relationship is crucial for optimizing hypertension management.

Purpose of the Study:

  • To investigate the temporal association between arterial stiffness and BP in patients undergoing antihypertensive treatment.
  • To determine whether changes in arterial stiffness precede or follow changes in BP.

Main Methods:

  • Utilized data from 3277 patients with treated hypertension from the Kailuan study (2010-2016).
  • Repeated measurements of branchial-ankle pulse wave velocity (baPWV) and BP were collected.
  • Cross-lagged path analyses were employed to assess the temporal relationship between baPWV and BP.

Main Results:

  • Reduced arterial stiffness (higher baseline baPWV) was a significant predictor of subsequent systolic BP (SBP) reduction (regression coefficient 0.14, P < 0.0001).
  • The yearly rate of SBP change varied significantly with baseline baPWV quartiles (P < 0.0001).
  • Conversely, yearly baPWV change did not significantly vary with baseline SBP quartiles (P = 0.2443).

Conclusions:

  • Findings provide strong evidence that reducing arterial stiffness can precede and potentially drive BP lowering in treated hypertensive patients.
  • This suggests that therapies targeting arterial stiffness may be effective in managing hypertension.
  • The results highlight the importance of assessing and managing arterial stiffness in hypertensive individuals.
Abstract

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