Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Why do skin grafts fail?

B T Teh

    Plastic and Reconstructive Surgery
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Fibrin deposition is crucial for wound healing and skin graft success. Bacterial enzymes that degrade fibrin cause graft failure, not bacterial numbers alone.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mutational Signatures in Mandibular Ameloblastoma Correlate with Smoking.

    Journal of dental research·2019
    Same author

    Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma.

    Leukemia·2018
    Same author

    Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape.

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same author

    Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.

    Oncogene·2017
    Same author

    JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma.

    Leukemia·2016
    Same author

    Haem oxygenase 1 expression is associated with prognosis in cholangiocarcinoma patients and with drug sensitivity in xenografted mice.

    Cell proliferation·2016
    Same journal

    Building Practical Artificial Intelligence Tools For The Plastic Surgeon: A Step-By-Step Guide To Cowork.

    Plastic and reconstructive surgery·2026
    Same journal

    Interpretation Matters: Common Statistical Pitfalls in Retrospective Surgical Research.

    Plastic and reconstructive surgery·2026
    Same journal

    "Inferior Repositioning of the High-Riding Nipple Using a Parenchymal-Based Flap".

    Plastic and reconstructive surgery·2026
    Same journal

    A Four-Step Strategy for the Treatment of Facial Rhytids: A Focus on Upper Facial Wrinkles.

    Plastic and reconstructive surgery·2026
    Same journal

    Evaluating Long-Term Retention of Fresh-Frozen Costal Cartilage Allograft in An Animal Model.

    Plastic and reconstructive surgery·2026
    Same journal

    Manual extrusion of fat granules for primary thinning of a bulky flap.

    Plastic and reconstructive surgery·2026
    See all related articles

    Area of Science:

    • Wound healing
    • Tissue engineering
    • Microbiology

    Background:

    • Fibrin is essential for the adherence of biological dressings and autografts to wounds.
    • The presence of fibrin correlates with successful graft outcomes, while its absence indicates failure.

    Purpose of the Study:

    • To elucidate the role of fibrin in wound healing and skin graft success.
    • To identify the mechanisms by which bacteria influence skin graft outcomes.

    Main Methods:

    • The study observed the presence and absence of fibrin in relation to graft success or failure.
    • Bacterial mechanisms affecting fibrin were investigated.

    Main Results:

    • Fibrin deposition is the primary factor for biological dressing adherence and autograft success.

    Related Experiment Videos

  • Fibrin provides an anti-bacterial effect and aids in wound sterilization under grafts.
  • Bacterial plasmin and proteolytic enzymes degrade the fibrin scaffold, leading to graft failure.

    • Conclusions:

    • Fibrin's presence is critical for successful skin grafting and wound healing.
    • Bacterial enzymes targeting fibrin, rather than bacterial load, determine graft success or failure.