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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

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Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific

Elisabeth Meedt¹, Daniela Weber¹, Agnes Bonifacius²

¹Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|March 8, 2023

Abstract:

We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.

Keywords:

CAEBV EBV-specific T cells allogeneic stem cell transplantation anti-T-lymphocyte globulin

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