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SiO2@Au nanoshell-assisted laser desorption/ionization mass spectrometry for coronary heart disease diagnosis

Yanyan Li1, Hua Zhang1, Jingjing Jiang2

  • 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, 610065, China. yunbing.wang@scu.edu.cn.

Journal of Materials Chemistry. B
|March 8, 2023
PubMed

Insights

This study developed a novel nanomaterial for analyzing coronary heart disease (CHD) metabolism using mass spectrometry. The method shows promise for distinguishing CHD patients from healthy individuals.

Area of Science:

  • Biochemistry
  • Materials Science
  • Medical Diagnostics

Background:

  • Cardiovascular diseases, particularly coronary heart disease (CHD), are a leading cause of mortality worldwide.
  • CHD is recognized as a metabolic disorder, yet its metabolic pathways remain under-researched.
  • Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) offers potential for metabolic profiling but requires optimized sample handling.

Purpose of the Study:

  • To develop and optimize a nanomaterial-based approach for high-quality metabolic fingerprinting of CHD.
  • To investigate the utility of SiO2@Au nanoshells combined with plasma for CHD metabolic analysis.
  • To determine the diagnostic accuracy of this novel method for identifying CHD.

Main Methods:

  • Fabrication and optimization of SiO2@Au nanoshells for enhanced laser desorption/ionization.
  • Application of the optimized nanoshells with minute plasma samples for metabolic fingerprinting.
  • Utilizing MALDI-MS for analyzing metabolic profiles of coronary heart disease patients and controls.
  • Validation of the method's performance in distinguishing CHD cases from controls.

Main Results:

  • Successful combination of SiO2@Au nanoshells with plasma for metabolic profiling of CHD.
  • Optimization of SiO2@Au shell thickness to improve the MALDI-MS signal.
  • Achieved 84% sensitivity and 85% specificity in distinguishing CHD patients from controls in a validation cohort.

Conclusions:

  • The developed SiO2@Au nanoshell-based MALDI-MS method provides a sensitive and specific approach for CHD metabolic fingerprinting.
  • This technique offers a promising tool for the non-invasive diagnosis and metabolic study of coronary heart disease.
  • Further research can explore the clinical application of this nanomaterial-based diagnostic strategy.

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