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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

345
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
345
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

693
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
693

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Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.

Yamin Zhang1,2, Fei Liu1,2,3, Yuhe Zhang1,2

  • 1Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208.

Proceedings of the National Academy of Sciences of the United States of America
|March 8, 2023
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Summary

This study introduces a novel, light-controlled, bioresorbable drug delivery system. The implantable device uses light to trigger drug release, offering a programmable and self-powered alternative to surgical implants for sustained medication.

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batterybioresorbabledrug deliverylight-controlledself-powered

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Implantable Electronics

Background:

  • Sustained drug release often relies on passive polymer matrices or scaffolds.
  • Active drug delivery systems typically require surgical implantation and removal.
  • Existing technologies lack precise, external control over drug release kinetics.

Purpose of the Study:

  • To develop a light-controlled, self-powered, and bioresorbable drug delivery technology.
  • To enable programmable and tailored drug release profiles for patient-specific needs.
  • To overcome the limitations of current implantable drug delivery systems.

Main Methods:

  • Utilized a wavelength-sensitive phototransistor to trigger an electrochemical cell.
  • Engineered a bioresorbable metal gate valve anode that corrodes upon light stimulation.
  • Implemented a wavelength-division multiplexing strategy for programming multiple drug reservoirs.
  • Investigated various bioresorbable electrode materials for optimized device design.

Main Results:

  • Demonstrated light-induced electrochemical corrosion of the gate valve, releasing drugs.
  • Successfully programmed drug release from individual or multiple reservoirs within the integrated device.
  • Validated the system's functionality through in vivo studies in rat models.
  • Showcased programmed release of lidocaine near sciatic nerves for pain management.

Conclusions:

  • The developed technology offers a promising bioresorbable and light-controlled approach to drug delivery.
  • This system provides precise pharmacokinetic control, bypassing the need for surgical extraction.
  • Potential applications include pain management and treatment of various diseases requiring tailored drug release.