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Updated: Aug 7, 2025
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Efficiency analysis of commercial polymeric membranes for bone regeneration in rat cranial defects
Lana Karine Araújo1, Mirrael de Sousa Lopes2, Francisco Fábio Pereira de Souza3
1Universidade Federal do Ceará - Postgraduate Program in Biotechnology - Sobral (CE), Brazil.
Purpose:
To evaluate the in vivo efficiency of commercial polymeric membranes for guided bone regeneration.
Methods:
Rat calvarial critical size defects was treated with LuminaCoat (LC), Surgitime PTFE (SP), GenDerm (GD), Pratix (PR), Techgraft (TG) or control (C-) and histomorphometric analysis determined the percentage of new bone, connective tissue and biomaterial at 1 or 3 months. Statistical analysis used ANOVA with Tukey's post-test for means at same experimental time and the paired Student's t test between the two periods, considering p < 0.05.
Results:
New bone at 1 month was higher for SP, TG and C-, at 3 months there were no differences, and between 1 and 3 months PR had greater increase growthing. Connective tissue at 1 month was higher for C-, at 3 months for PR, TG and C-, and between 1 and 3 months C- had sharp decline. Biomaterial at 1 month was higher for LC, in 3 months for SP and TG, and between 1 and 3 months, LC, GD and TG had more decreasing mean.
Conclusions:
SP had greater osteopromotive capacity and limitation of connective ingrowth, but did not exhibit degradation. PR and TG had favorable osteopromotion, LC less connective tissue and GD more accelerated biodegradation.
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