[Ifosfamide treatment for children with malignant tumor]

Seven drugs were administered to nude mice with transplanted TNB9 neuroblastoma. DTIC, cyclophosphamide and ifosfamide were the first-line drugs against TNB9. Chemotherapy including ifosfamide was effective to three of six children with malignant solid tumor resistant to cisplatin and/or cyclophosphamide. Two of the patients who were pretreated with radiotherapy were found to have hemorrhagic cystitis after ifosfamide administration. It therefore seems that chemotherapy with ifosfamide should be withheld after radiotherapy.