Highly hygroscopicity and antioxidant nanofibrous dressing base on alginate for accelerating wound healing

The removal of bacterium and free radicals is important for wound healing. Therefore, it is necessary to prepare biological dressings with antibacterial and antioxidant properties. In this study, high-performance calcium alginate/carbon polymer dots/forsythin composite nanofibrous membrane (CA/CPDs/FT) was explored under the influence of carbon polymer dots and forsythin. The addition of carbon polymer dots improved the nanofiber morphology and therefore enhanced the mechanical strength of the composite membrane. Moreover, CA/CPDs/FT membranes displayed satisfactory antibacterial and antioxidant properties because of the natural properties of forsythin. Meanwhile, outstanding hygroscopicity over 700% was also obtained for the composite membrane. In vitro and in vivo experiments showed that the CA/CPDs/FT nanofibrous membrane could prevent the invasion of bacteria, scavenge free radicals, and promote wound healing. Moreover, its good hygroscopicity and antioxidation characteristics were friendly for the clinical application of high-exudate wounds.