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Risk Factors and Age-Related Patterns of Asthma-Like Symptoms in Early Childhood

Julie Nyholm Kyvsgaard1, Bo Lund Chawes2, David Lyle George Horner2

  • 1COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Pediatrics, Slagelse Hospital, Slagelse, Denmark.

The Journal of Allergy and Clinical Immunology. in Practice
|March 8, 2023
PubMed

Insights

Identifying risk factors for childhood asthma-like symptoms is crucial. Male sex, maternal asthma, and low birth weight significantly increased symptom episodes in the first three years of life.

Area of Science:

  • Pediatrics
  • Respiratory Medicine
  • Epidemiology

Background:

  • Childhood asthma-like symptoms are common, yet risk factors and daily symptom burden patterns remain poorly understood.
  • Early identification of risk factors is essential for understanding disease progression.

Purpose of the Study:

  • To investigate risk factors for asthma-like symptoms in children aged 0-3 years.
  • To analyze the age-related impact of these risk factors on symptom burden.

Main Methods:

  • Prospective cohort study of 700 children from birth.
  • Daily symptom diaries recorded until age 3.
  • Quasi-Poisson regressions used to analyze risk factors and age interactions.

Main Results:

  • Male sex, maternal asthma, low birth weight, maternal antibiotic use, high asthma polygenic risk score, and high airway immune score were associated with increased symptom episodes.
  • Maternal asthma, preterm birth, C-section, and low birth weight showed increasing impact with age.
  • Each additional clinical risk factor (male sex, low birth weight, maternal asthma) increased episodes by 34%.

Conclusions:

  • Identified key risk factors and their age-specific patterns for asthma-like symptoms in early childhood.
  • Novel insights into the origins of childhood asthma-like symptoms.
  • Findings may inform personalized prognostics and treatment strategies.
Abstract

Keywords:
AsthmaChildRespiratory patternRespiratory symptomsRisk FactorsWheeze

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