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Curcumin effects on chronic obstructive pulmonary disease: A systematic review.
Saeid Safari1,2, Poorya Davoodi2,3, Afsaneh Soltani4,5
1Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence Shahid Beheshti University of Medical Sciences Tehran Iran.
Health Science Reports
|March 9, 2023
Summary
Curcumin shows potential benefits for managing Chronic Obstructive Pulmonary Disease (COPD) by reducing inflammation and oxidative stress. Further clinical trials are needed to confirm its efficacy in COPD patients.
Area of Science:
- Pulmonary Medicine
- Pharmacology
- Natural Products Chemistry
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality globally, with frequent exacerbations requiring interventions.
- Current COPD treatments have limitations and potential adverse effects.
- Curcumin, a natural compound, possesses anti-inflammatory and antiproliferative properties.
Purpose of the Study:
- To systematically review the existing literature on the effects of Curcumin in the context of COPD.
- To evaluate the potential of Curcumin as an adjunct or alternative therapy for COPD management.
Main Methods:
- A systematic review was conducted following the PRISMA checklist.
- Searches were performed in PubMed/Medline, Scopus, and Web of Science for studies published in the last 10 years.
- Inclusion criteria focused on studies investigating COPD and Curcumin, excluding reviews, preprints, and non-English articles.
Main Results:
- Nine articles were included from an initial search of 4288 publications.
- Curcumin demonstrated inhibitory effects on alveolar epithelial proliferation and thickness.
- Evidence suggests Curcumin can reduce inflammation, oxidative stress, and emphysema progression in COPD models.
Conclusions:
- Curcumin exhibits promising modulatory effects on oxidative stress, cell viability, and gene expression relevant to COPD.
- These findings suggest Curcumin could be beneficial in managing COPD.
- Further randomized clinical trials are necessary to validate these therapeutic potentials.
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