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MicroRNA-183/96/182 cluster in immunity and autoimmunity

Zhuang Wang1, Rujuan Dai1, Sattar Ansar Ahmed1

  • 1Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine (VMCVM), Virginia Tech, Blacksburg, VA, United States.

Frontiers in Immunology
|March 9, 2023
PubMed

Insights

The miR-183/96/182 cluster (miR-183C) of microRNAs plays a complex role in immune cell function. Dysregulation of miR-183C is implicated in autoimmune diseases, suggesting potential as biomarkers and therapeutic targets.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression.
  • The miR-183/96/182 cluster (miR-183C) comprises three miRNAs with similar seed sequences, enabling cooperative yet distinct gene targeting.
  • miR-183C was initially found in sensory organs but is now recognized for its role in various diseases.

Purpose of the Study:

  • To review the multifaceted role of miR-183C in immune cell differentiation and function.
  • To explore the dysregulation of miR-183C in autoimmune diseases.
  • To discuss the potential of miR-183C as biomarkers and therapeutic targets in autoimmune conditions.

Main Methods:

  • Literature review focusing on miR-183C function in immunity.
  • Analysis of studies investigating miR-183C expression in normal and autoimmune contexts.
  • Synthesis of evidence regarding miR-183C's impact on innate and adaptive immunity.

Main Results:

  • miR-183C miRNAs regulate the differentiation and function of both innate and adaptive immune cells.
  • Abnormal expression of miR-183C is observed in various cancers and autoimmune diseases.
  • Specific autoimmune diseases like systemic lupus erythematosus (SLE), multiple sclerosis (MS), and ocular autoimmune disorders show miR-183C dysregulation.

Conclusions:

  • miR-183C miRNAs have a complex role in immune cells under both normal and autoimmune conditions.
  • Dysregulated miR-183C presents potential as biomarkers for specific autoimmune diseases.
  • Targeting miR-183C offers a promising therapeutic strategy for autoimmune disorders.
Keywords:
autoimmuneautoinflammatory diseasesepigenetic regulationimmunitymiR-183/96/182 clustermicroRNA

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