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Next-generation Sequencing

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Updated: Aug 7, 2025

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Next-generation liquid biopsy instruments: Challenges and opportunities.

Shu Zhu¹, Yaohui Fang¹, Kefan Guo¹

¹School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, P. R. China.

Electrophoresis

|March 9, 2023

Summary

Liquid biopsy (LB) offers a less invasive method for real-time cancer diagnosis compared to traditional tissue biopsy. Current LB instruments face limitations, but future advancements aim for clinical integration.

Keywords:

cancer diagnosis liquid biopsy minimal invasiveness next-generation

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Last Updated: Aug 7, 2025

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

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Published on: September 9, 2020

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Area of Science:

Oncology
Medical Diagnostics
Biotechnology

Background:

Conventional cancer diagnosis relies on invasive tissue biopsies, causing patient harm.
Liquid biopsy (LB) presents a minimally invasive alternative for real-time cancer detection and monitoring.
Existing LB instruments are not yet widely adopted as replacements for tissue biopsies in clinical practice.

Purpose of the Study:

To review the current challenges and limitations of existing liquid biopsy instruments.
To explore opportunities and future directions for developing next-generation liquid biopsy tools.
To discuss the potential integration of advanced LB instruments into clinical workflows for cancer diagnosis.

Main Methods:

Literature review and analysis of current liquid biopsy technologies.
Identification and categorization of limitations in existing diagnostic instruments.
Exploration of emerging trends and potential innovations in liquid biopsy.

Main Results:

Several key challenges hinder the widespread clinical use of current liquid biopsy instruments.
Significant opportunities exist for technological advancements to overcome these limitations.
Future liquid biopsy instruments require validation to become reliable diagnostic tools.

Conclusions:

Liquid biopsy technology holds great promise for cancer diagnosis but requires further development.
Overcoming current instrument limitations is crucial for clinical adoption.
The goal is to establish liquid biopsy as a validated, integrated tool in cancer diagnostics.