Related Experiment Video

Updated: Aug 7, 2025

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay
08:18

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay

Published on: January 7, 2019

9.1K

Evaluation of hypercholesterolemia management in at-risk patients by cardiologists in France: a case vignette-based

Jean Ferrières1,2, Eric Bruckert3, Michel Farnier4

  • 1Department of Cardiology, Toulouse Rangueil University Hospital, Toulouse University School of Medicine, Toulouse, France.

Journal of Comparative Effectiveness Research
|March 9, 2023
PubMed

Insights

French cardiologists frequently underestimate cardiovascular risk and LDL-C targets in hypercholesterolemia patients. Guideline-recommended treatments for high-risk patients were often not followed.

Area of Science:

  • Cardiology
  • Lipidology
  • Public Health

Background:

  • Hypercholesterolemia management is crucial for cardiovascular risk reduction.
  • Current guidelines recommend specific low-density lipoprotein cholesterol (LDL-C) targets based on cardiovascular risk.
  • Adherence to guidelines ensures optimal patient outcomes.

Purpose of the Study:

  • To investigate the lipid-lowering strategies employed by French cardiologists.
  • To assess the accuracy of cardiovascular risk categorization and LDL-C target selection in high- and very high-risk patients.
  • To evaluate the alignment of prescribed treatments with current clinical guidelines.

Main Methods:

  • An online interactive survey was conducted among French cardiologists.
  • Physicians assessed three hypothetical patients with hypercholesterolemia.
  • Key assessments included cardiovascular risk category, target LDL-C, and treatment selection.

Main Results:

  • 162 physicians completed 480 risk assessments.
  • Only 58% of assessments correctly categorized patient cardiovascular risk.
  • Higher-than-recommended LDL-C targets were frequently selected, and statin therapy was common, but often less intensive than recommended.

Conclusions:

  • French cardiologists may underestimate cardiovascular risk in hypercholesterolemia.
  • There is a tendency to set higher LDL-C targets and prescribe less intensive treatments than guidelines suggest.
  • Improved adherence to lipid-lowering guidelines is needed for optimal cardiovascular risk management.

Keywords:
Francecardiologistscardiovascular riskcase-vignetteezetimibehypercholesterolemialipid-loweringonline interactive surveystatintreatment

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
30
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
19
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
21
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
12
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
27