Related Experiment Video
Updated: Aug 7, 2025
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
TRIM27 expression is associated with poor prognosis in sinonasal mucosal melanoma
S Kimura1, M Suzuki1, Y Nakamaru1
1Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Background:
Tripartite motif-containing 27 (TRIM27) has been implicated in the progression of various cancers. However, the role of TRIM27 in sinonasal mucosal melanoma (SNMM) remains poorly understood.
Materials & Methods:
We retrospectively examined 28 patients with SNMM treated with between 2003 and 2021. We undertook immunohistochemical analysis of TRIM27, Ki-67, and p-Akt1 expression in SNMM tissues. We also investigated the relationship between TRIM27 expression and clinical characteristics, prognosis, Ki-67 as a tumor growth potential marker, and p-Akt1 as one of the prognostic factors in mucosal melanoma.
Results:
TRIM27 expression was significantly higher in T4 disease than in T3 disease and was higher in stage IV than in stage III. Patients with high-TRIM27 SNMM had a significantly poorer prognosis in terms of overall survival (OS) and disease-free survival.There was also a significantly higher rate of distant metastasis. Univariate analysis for OS revealed that TRIM27 and T classification were significant poor prognostic factors. In addition, the Ki-67 positive score and the p-Akt1 total staining score were significantly higher in the high-TRIM27 group than in the low-TRIM27 group.
Conclusions:
High TRIM27 expression in SNMM was associated with advanced T classification, poor prognosis and distant metastasis. We suggest that TRIM27 has potential as a novel biomarker for prognosis in SNMM.
Insights
High TRIM27 expression in sinonasal mucosal melanoma (SNMM) correlates with advanced disease and poor prognosis. This suggests TRIM27 may serve as a novel biomarker for predicting outcomes in SNMM patients.
Area of Science:
- Oncology
- Cancer Research
- Melanoma Research
Background:
- Tripartite motif-containing 27 (TRIM27) is linked to various cancer progressions.
- The specific role of TRIM27 in sinonasal mucosal melanoma (SNMM) is not well-defined.
Purpose of the Study:
- To investigate the expression and prognostic significance of TRIM27 in SNMM.
- To explore the relationship between TRIM27, tumor characteristics, and patient outcomes.
Main Methods:
- Retrospective analysis of 28 SNMM patients treated between 2003 and 2021.
- Immunohistochemical analysis of TRIM27, Ki-67, and p-Akt1 expression in tumor tissues.
- Correlation of TRIM27 levels with clinical features and survival data.
Main Results:
- Higher TRIM27 expression observed in advanced T classification (T4 vs. T3) and stage IV disease.
- Elevated TRIM27 levels were associated with significantly poorer overall survival and disease-free survival.
- High TRIM27 expression correlated with increased distant metastasis rates and higher Ki-67 and p-Akt1 scores.
Conclusions:
- High TRIM27 expression is linked to advanced stage, poor prognosis, and distant metastasis in SNMM.
- TRIM27 shows potential as a novel prognostic biomarker for sinonasal mucosal melanoma.
