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Polycaprolactone-MXene Nanofibrous Scaffolds for Tissue Engineering.

Kateryna Diedkova1,2, Alexander D Pogrebnjak1,3,4, Sergiy Kyrylenko1

  • 1Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.

ACS Applied Materials & Interfaces
|March 9, 2023
PubMed
Summary

New conductive biomaterials combining polycaprolactone (PCL) and MXene show promise for tissue engineering. These PCL-MXene scaffolds offer improved conductivity and support cell growth, advancing regenerative medicine strategies.

Keywords:
MXeneconductive biomaterialselectrospinningporous scaffoldtissue engineering

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Conductive biomaterials are crucial for regenerating nervous, muscular, and heart tissues.
  • Polycaprolactone (PCL) nanofiber scaffolds offer biocompatibility and biodegradability but lack conductivity.
  • MXenes are 2D nanomaterials that can impart conductivity and hydrophilicity to polymer scaffolds.

Purpose of the Study:

  • To investigate the physical properties of MXene-functionalized PCL nanofiber scaffolds.
  • To correlate the electronic structure and defects of MXene with the biological performance of the scaffolds.
  • To evaluate the potential of PCL-MXene composites as conductive biomaterials for tissue engineering.

Main Methods:

  • Fabrication of electrospun PCL membranes with immobilized Ti3C2Tx MXene layers.
  • Positron annihilation analysis to characterize defect structure and porosity.
  • Electrical conductivity measurements across a wide temperature range.
  • In vitro biological evaluation including cell attachment, proliferation, and bacterial adhesion tests.

Main Results:

  • PCL scaffolds exhibited nanopores, while MXene layers showed abundant vacancies and voltage resonance.
  • Positron lifetime analysis revealed temperature-dependent defect structures.
  • PCL-MXene composites demonstrated tunable conductivity with inductive and capacity components.
  • Multiple MXene coatings promoted cell attachment and proliferation while exhibiting mild antibacterial effects.

Conclusions:

  • PCL-MXene composite scaffolds possess advantageous structural, chemical, electrical, and biological properties.
  • The developed conductive biomaterials show potential for applications in tissue engineering.
  • MXene-coated PCL membranes represent a promising alternative to existing conductive scaffolds.