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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
Published on: December 13, 2017
Recent Advances in Cardiovascular Disease Biosensors and Monitoring Technologies
Lichao Tang1,2, Jiyuan Yang1,3, Yuxi Wang1,4
1Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Insights
Early diagnosis of cardiovascular disease (CVD) is crucial for reducing mortality. Novel biosensors offer rapid, continuous monitoring of cardiac biomarkers and heartbeat signals, improving upon traditional methods.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiology
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- Traditional CVD diagnosis involves inconvenient, time-consuming hospital-based electrocardiography and immunoassay analysis.
- There is a critical need for accessible and rapid CVD detection methods.
Purpose of the Study:
- To review the current landscape of biosensing technologies for cardiovascular disease.
- To summarize common CVD categories, cardiac biomarkers, and heartbeat signal analysis.
- To introduce emerging wearable and implantable biosensors for continuous CVD monitoring.
Main Methods:
- Review of prevalence and categories of CVD.
- Summary of clinical cardiac biomarkers and heartbeat signals for prognosis.
- Introduction and comparison of various biosensing methodologies (chemical, electrochemical, optical, electromechanical).
- Discussion of emerging wearable and implantable biosensors.
Main Results:
- Biosensing technologies enable rapid screening, accurate quantification, and continuous monitoring of CVD markers.
- Advancements in nanotechnology and bioelectronics are driving novel biosensor platforms.
- Wearable and implantable devices offer potential for real-time CVD monitoring.
Conclusions:
- Biosensors represent a significant advancement over traditional CVD diagnostic tools.
- Future research should focus on optimizing biosensor performance and integration for comprehensive CVD management.
- Continuous monitoring via biosensors can lead to improved patient outcomes and reduced CVD mortality.
Abstract:
Cardiovascular disease (CVD) causes significant mortality and remains the leading cause of death globally. Thus, to reduce mortality, early diagnosis by measurement of cardiac biomarkers and heartbeat signals presents fundamental importance. Traditional CVD examination requires bulky hospital instruments to conduct electrocardiography recording and immunoassay analysis, which are both time-consuming and inconvenient. Recently, development of biosensing technologies for rapid CVD marker screening attracted great attention. Thanks to the advancement in nanotechnology and bioelectronics, novel biosensor platforms are developed to achieve rapid detection, accurate quantification, and continuous monitoring throughout disease progression. A variety of sensing methodologies using chemical, electrochemical, optical, and electromechanical means are explored. This review first discusses the prevalence and common categories of CVD. Then, heartbeat signals and cardiac blood-based biomarkers that are widely employed in clinic, as well as their utilizations for disease prognosis, are summarized. Emerging CVD wearable and implantable biosensors and monitoring bioelectronics, allowing these cardiac markers to be continuously measured are introduced. Finally, comparisons of the pros and cons of these biosensing devices along with perspectives on future CVD biosensor research are presented.
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