Related Experiment Video
Updated: Aug 7, 2025
07:41
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
Published on: July 12, 2024
2.4K
Evaluation of Gum Arabic Double-layer Microneedle Patch Containing Sumatriptan for Loading and Transdermal Delivery
Xiaoduo Zhang1, Weijun Liu1, Wei Wang2
1School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, 201418, China.
Current Drug Delivery
|March 9, 2023
Summary
New acacia-derived microneedles offer rapid, self-administered migraine relief. These dissolving microneedles effectively deliver sumatriptan, comparable to injections, for optimal headache treatment.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Migraineurs require optimal self-treatment for acute headache episodes.
- A rapidly dissolving double-layer microneedle system derived from natural acacia was developed for this purpose.
Purpose of the Study:
- To develop and characterize a novel acacia-derived microneedle system for sumatriptan delivery.
- To evaluate the mechanical properties, dissolution, and drug release kinetics of the microneedles.
Main Methods:
- Acacia (GA) underwent ionic crosslinking under optimized conditions.
- Double-layer microneedles loaded with sumatriptan were fabricated.
- Mechanical strength, dissolution, in vitro release, and chemical composition were analyzed.
Main Results:
- Microneedles contained approximately 10.89 μg of crosslinked acacia and 1.821 μg of sumatriptan.
- Microneedles demonstrated excellent solubility, sufficient mechanical stiffness for skin penetration, and dissolved within 240s.
- Histological analysis confirmed insertion depth of 300 ± 28 μm, with near-complete drug release within 40 minutes.
Conclusions:
- The drug release from the acacia microneedles was comparable to subcutaneous injection.
- This novel microneedle system presents a promising new avenue for migraine self-treatment.
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
426
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
426
01:15Non-Oral Extravascular Drug Absorption Routes
259
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
259
01:18Drug Delivery: Enteral Route
554
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
554