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The functional importance of bacterial oxidative phosphonate pathways
Katharina Pallitsch1, David L Zechel2
1Institute of Organic Chemistry, Faculty of Chemistry, University of Vienna, Währingerstraße 38, 1090 Vienna.
Biochemical Society Transactions
|March 9, 2023
Summary
Oxidative enzymes are crucial for microbial metabolism of organophosphonates (Pns), driving structural diversity and breakdown. These enzymes, particularly iron-dependent ones, mediate unique reactions essential for Pn biochemistry.
Area of Science:
- Biochemistry
- Microbiology
- Natural Products Chemistry
Background:
- Organophosphonates (Pns) are natural products with a stable C-P bond, exhibiting diverse bioactivities.
- Microbial metabolism of Pns is not fully understood, yet involves unique chemical transformations.
- Oxidative enzymes are key players in both the synthesis and degradation of Pns.
Conclusions:
- Microbial Pn metabolism involves a combination of classical redox biochemistry and specialized oxidative reactions.
- Oxidative enzymes are essential for Pn pathway diversification and functionalization.
- Understanding these enzymes offers insights into Pn biochemistry and potential applications.
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