Design of a highly sensitive and versatile membrane-based immunosensor using a Cu-free click reaction
Hiroto Okuyama1, Yukari Kodama1, Kazuya Takemura1
1Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan. yamag@res.titech.ac.jp.
Analytical Methods : Advancing Methods and Applications
|March 9, 2023
Abstract:
A highly sensitive immunosensor is developed using membrane pores as the recognition interface. In this sensor, a Cu-free click reaction is used to efficiently immobilize antibodies, and the sensor inhibits the adsorption of nonspecific proteins that degrade sensitivity. Furthermore, the sensor demonstrates rapid interleukin-6 detection in the picogram per milliliter range.
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