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Pro-and Antioxidant Status in Newborn with COVID-19
L V Rychkova1, M A Darenskaya2, A G Petrova1
1Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Insights
Newborns with COVID-19 exhibit oxidative stress, indicated by elevated lipid peroxidation products and altered antioxidant enzyme activity. These findings highlight the susceptibility of infants to coronavirus infection and the need for close metabolic monitoring.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Biochemistry
Background:
- Limited data exists on oxidative stress in newborns with COVID-19.
- Understanding neonatal reactivity to infections is crucial for different age groups.
- COVID-19 poses risks to newborns, necessitating further investigation.
Purpose of the Study:
- To assess pro- and antioxidant status indicators in newborns with confirmed COVID-19.
- To investigate the impact of coronavirus infection on neonatal oxidative stress.
- To contribute to a better understanding of COVID-19's effects on infant metabolism.
Main Methods:
- Studied 44 newborns diagnosed with COVID-19.
- Measured levels of lipid peroxidation (LPO) products.
- Assessed activity of superoxide dismutase (SOD) and glutathione peroxidase, and retinol levels.
Main Results:
- Elevated levels of unsaturated double bond compounds, primary, secondary, and final LPO products were observed.
- Increased SOD activity and retinol levels were noted.
- Reduced glutathione peroxidase activity was found in infected newborns.
Conclusions:
- Newborns demonstrate significant oxidative stress during COVID-19 infection.
- These metabolic changes suggest newborns are a susceptible population to COVID-19.
- Close monitoring of metabolic reactions during neonatal adaptation is essential for infected infants.
Abstract:
There is practically no information on the state of oxidative stress reactions in newborns with coronavirus infections. At the same time, such studies are extremely important and can contribute to better understanding of the process of reactivity in patients of different ages. The content of pro- and antioxidant status indicators was assessed in 44 newborns with confirmed COVID-19. It was found that the content of compounds with unsaturated double bonds, primary, secondary, and final LPO products were elevated in newborns with COVID-19. These changes were accompanied by higher SOD activity and retinol level and reduced activity of glutathione peroxidase. Contrary to popular opinion, newborns can be a COVID-19-susceptible age group and require more close monitoring of metabolic reactions during the period of neonatal adaptation that is an aggravating background during infection.
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