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Off-label tenecteplase use in spinal cord ischemia

Daniela Santos Oliveira1, Luísa Sousa2

  • 1Neurology Department, Centro Hospitalar de Entre o Douro e Vouga, Rua Dr. Cândido Pinho, nº 5, 4520-220, Santa Maria da Feira, Portugal. daniela.s.oliveira29@gmail.com.

Acta Neurologica Belgica
|March 9, 2023
PubMed
Summary

No abstract available in PubMed .

Keywords:
AlteplaseAnterior spinal artery syndromeSpinal cord infarctionTenecteplaseThrombolysisTreatment

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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