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Updated: Aug 7, 2025

CD Spectroscopy to Study DNA-Protein Interactions
Published on: February 10, 2022
Chiroptical Properties of Z-DNA Using Ionic Porphyrins and Metalloporphyrins
1Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Catania, Italy. adurso@unict.it.
Abstract:
The non-covalent interaction of achiral porphyrins with nucleic acids has been extensively studied, and various macrocycles have been indeed utilized as reporters of different sequences of DNA bases. Nevertheless, few studies have been published on the capability of these macrocycles to discriminate among the various nucleic acid conformations. Circular dichroism spectroscopy allowed to characterize the binding of several cationic and anionic mesoporphyrins and metallo derivatives with Z-DNA, in order to exploit the functionality of these systems as probes, storing system, and logic gate.
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