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3D-printed eye model: Simulation of intraocular pressure
Hidenaga Kobashi1,2, Masaaki Kobayashi3
1Toneasy Inc., Tokyo, Japan.
Plos One
|March 9, 2023
Summary
3D printed artificial eyes accurately model intraocular pressure (IOP) and show a strong correlation between corneal thickness and IOP. This 3D printing technique offers a promising alternative to traditional animal models for IOP research.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Materials Science
Background:
- Intraocular pressure (IOP) is a critical factor in glaucoma management.
- Traditional methods for IOP measurement often rely on animal models, which have limitations.
- Developing accurate artificial eye models is essential for research and training.
Purpose of the Study:
- To create artificial eye models utilizing 3D printing technology.
- To investigate the relationship between varying corneal thicknesses and IOP measurements.
- To assess the viability of 3D printed models as an alternative to conventional methods.
Main Methods:
- Designed and fabricated seven artificial eye models using computer-aided design and 3D printing.
- Incorporated Gullstrand eye model parameters for corneal curvature and axial length.
- Varied corneal thicknesses from 200 to 800 μm and adjusted corneal stiffness.
- Utilized a Tono-Pen AVIA tonometer for consistent IOP measurements.
Main Results:
- Successfully developed functional 3D printed artificial eye models.
- Achieved reliable IOP measurements across all fabricated models.
- Demonstrated a significant correlation between corneal thickness and IOP (R² = 0.927, P < 0.001).
Conclusions:
- 3D printed artificial eye models are effective for IOP evaluation.
- This innovative technique presents a viable alternative to porcine eye models.
- 3D printing offers a reproducible and customizable approach for ocular research.
