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Immunohistochemistry and Multiple Labeling with Antibodies from the Same Host Species to Study Adult Hippocampal Neurogenesis
Published on: April 22, 2015
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Response to Comment on "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than
Anneline Pinson1, Tomislav Maricic2, Hugo Zeberg3
1Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Science (New York, N.Y.)
|March 9, 2023
Abstract:
Herai et al. discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestral TKTL1 allele. Our paper demonstrates that the amino acid substitution in TKTL1 increases neural progenitor cells and neurogenesis in the developing brain. It is another question if, and to what extent, this has consequences for the adult brain.
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