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Post-ictal Rhythmic Thalamic Activity of the Centromedian Nucleus
Kristen Arredondo1, Adam P Ostendorf2, Stephanie Ahrens2
1Department of Neurology, The University of Texas at Austin Dell Medical School, Austin, TX, U.S.A.
Summary
Researchers identified a new EEG pattern, post-ictal rhythmic thalamic activity, in the centromedian nucleus of the thalamus (CMN) during epilepsy seizures. This finding may indicate the CMN
Area of Science:
- Neuroscience
- Epileptology
- Clinical Electrophysiology
Background:
- Deep brain stimulation of the centromedian nucleus of the thalamus (CMN) is a potential treatment for drug-resistant epilepsy.
- Electrophysiological activity of the CMN during seizures remains largely uncharacterized.
- A novel finding of post-ictal rhythmic thalamic activity in the CMN during seizures is described.
Purpose of the Study:
- To describe a novel electrophysiological finding in the centromedian nucleus of the thalamus (CMN) during seizures.
- To investigate the role of the CMN in seizure dynamics and termination.
Main Methods:
- Stereoelectroencephalography (SEEG) monitoring was performed in five patients with drug-resistant epilepsy.
- Bilateral CMN targets were included in the SEEG implantation plan.
- Seizure activity and CMN electrophysiological responses were analyzed.
Main Results:
- Centromedian nucleus of the thalamus (CMN) contacts were involved synchronously or rapidly after seizure onset, especially in frontal onset seizures.
- A distinct post-ictal rhythmic thalamic activity (1.5-2.5 Hz delta frequency) was observed in CMN contacts.
- This activity emerged during suppression of cortical background activity and correlated with seizure termination.
Conclusions:
- Post-ictal rhythmic thalamic activity in the CMN was observed in patients with convulsive seizures.
- This rhythm suggests a role for the CMN in seizure termination.
- The identified rhythm may aid in recognizing CMN involvement in epileptic networks.
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