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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Pharmacologic therapy among patients with type 2 diabetes mellitus admitted to the cardiology service
Evelyn Lesiawan1, Thomas Seaton1, Jocelyne Benatar1
1Green Lane Cardiovascular Service, Auckland City Hospital, 2 Park Road, Auckland.
Insights
Many patients with type 2 diabetes admitted to cardiology have poor glycemic control. Empagliflozin could benefit half of these patients, improving cardiovascular and renal outcomes.
Area of Science:
- Cardiology
- Endocrinology
- Diabetes Management
Background:
- Type 2 diabetes is a significant comorbidity in cardiology patients.
- Optimal diabetes management is crucial for improving cardiovascular and renal outcomes.
- Empagliflozin is a medication that offers benefits for both diabetes and cardiovascular health.
Purpose of the Study:
- To review diabetes management in type 2 diabetes patients admitted to cardiology.
- To assess the potential benefit of empagliflozin for these patients based on current guidelines.
- To identify opportunities for medication optimization in this patient population.
Main Methods:
- Retrospective audit of cardiology admissions from November 2020 to January 2021.
- Data collection included diabetes status, HbA1c levels, and current medications.
- Analysis focused on patient eligibility for empagliflozin.
Main Results:
- 98 out of 449 admissions (21.8%) had type 2 diabetes.
- 50% of patients had an HbA1c > 60 mmol/mol, indicating poor glycemic control.
- 50% of patients met criteria for potential empagliflozin eligibility.
Conclusions:
- A significant proportion of cardiology patients with type 2 diabetes experience suboptimal glycemic control.
- There is a missed opportunity for medication optimization, particularly in over-represented Pacific Peoples.
- Empagliflozin presents a targeted therapeutic option to address renal and cardiovascular risks in this cohort.
Aim:
To review the management of diabetes control in patients with type 2 diabetes admitted to the cardiology service at Auckland City Hospital for over 48 hours; to assess how many would potentially benefit from introduction of empagliflozin under current Pharmac guidelines.
Methods:
A retrospective audit of all admissions into cardiology between 1 November 2020 and 31 January 2021 prior to the availability of empagliflozin. Data collected included diagnosis and presence of type 2 diabetes, HbA1c and diabetes medications.
Results:
A total of 449 patients were admitted, of whom 98 had type 2 diabetes. The median age was 64 years old (IQR 56-76) and 66% of patients were male. Pacific peoples were over-represented in this study population. Fifty percent had an HbA1c>60mnmol/mol and diabetes medication was changed in 50% of these. Overall, 50% of patients would be eligible for empagliflozin under current criteria.
Conclusions:
High proportions of patients have poor glycaemic control and are not up-titrated, suggesting a missed opportunity for medication optimisation. Pacific peoples are over-represented in this group, suggesting that they are at high risk of diabetes and cardiovascular admissions. Empagliflozin provides a targeted way to address renal and cardiovascular outcomes.
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