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Subthalamic oscillatory activity during normal and impaired speech.

Franz Hell1, Annika Eißner2, Jan H Mehrkens3

  • 1Department of Neurology, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 Munich, Germany; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Grosshadernerstr. 2, 82152 Martinsried, Germany.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|March 9, 2023
PubMed
Summary

Subthalamic nucleus (STN) activity influences speech. Impaired beta suppression in the STN is linked to speech blocks, and deep brain stimulation may increase verbal task errors.

Keywords:
Deep brain stimulationFreezingOscillationsSpeechSubthalamic nucleusVerbal fluency

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Area of Science:

  • Neuroscience
  • Neurology
  • Speech Science

Background:

  • The subthalamic nucleus (STN) plays a role in motor control.
  • Oscillatory activity in the STN is implicated in various neurological conditions.
  • Understanding STN function is crucial for treating movement disorders affecting speech.

Purpose of the Study:

  • To investigate the relationship between subthalamic nucleus oscillatory activity and speech production.
  • To elucidate the functional role of the STN in verbal fluency and speech initiation.
  • To explore the impact of deep brain stimulation (DBS) on STN activity and speech performance.

Main Methods:

  • Simultaneous recording of STN local field potentials and audio during verbal fluency tasks in Parkinson's disease patients.
  • Analysis of oscillatory signals within the STN during speech production.
  • Assessment of error rates in verbal fluency tasks during DBS.

Main Results:

  • Normal speech is associated with suppressed alpha and beta power in the STN.
  • A patient experiencing speech initiation blocks showed increased beta power.
  • Deep brain stimulation (DBS) led to increased errors in verbal fluency tasks.

Conclusions:

  • Intact speech involves beta-band desynchronization in the STN.
  • Elevated beta synchronization in the STN may cause speech motor blocks.
  • DBS of the STN might impair response inhibition, leading to increased verbal task errors.