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Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA
J Van der Zee1, E Van Beek, T M Dubbelman
1Department of Medical Biochemistry, Sylvius Laboratories, Leiden, The Netherlands.
The Biochemical Journal
|October 1, 1987
Abstract:
Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appeared that both purines and pyrimidines were involved in DNA inter-strand and DNA-protein cross-links.