Elimination of A-234 from the environment: Effect of different decontaminants

With the fact that there are Novichoks in the list of toxic chemicals by the Chemical Weapons Convention parties, it is necessary to develop methods of effective neutralization of the agents as well as for other organophosphorus toxic substances. However, experimental studies on their persistence in the environment and effective decontamination measures remain scarce. Therefore, here, we investigated the persistence behavior and decontamination methods of A-234 (ethyl N-[1-(diethylamino)ethylidene]phosphoramidofluoridate), a Novichok series, A-type nerve agent to assess its potential risk to the environment. Different analytical methods were implemented, including ³¹P solid-state magic angle spinning nuclear magnetic resonance (NMR), liquid ³¹P NMR, gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry, and vapor-emission screening using a microchamber/thermal extractor with GC-MS. Our results showed that A-234 is extremely stable in sand and poses a long-lasting risk to the environment even when released in trace quantities. Moreover, the agent is not easily decomposed by water, dichloroisocyanuric acid sodium salt, sodium persulfate, and chlorine-based water-soluble decontaminants. However, it is efficiently decontaminated by Oxone® monopersulfate, calcium hypochlorite, KOH, NaOH, and HCl within 30 min. Our findings provide valuable insights for eliminating the highly dangerous Novichok agents from the environment.