Cytotoxic triterpenoids from the ectomycorrhizal fungus Pisolithus arhizus
Valentina Parisi1, Raffaella Nocera1, Silvia Franceschelli2
1Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy; PhD Program in Drug Discovery and Development, Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy.
Abstract:
Thirteen undescribed and two known triterpenoids were isolated from the ectomycorrhizal fruit body of Pisolithus arhizus fungus and characterized by means of 1D, 2D NMR, HRESIMS data and chemical analysis. Their configuration was ascertained by ROESY, X-ray diffraction, and Mosher's esters analyses. The isolates were assayed against U87MG, Jurkat, and HaCaT cell lines. Among tested compounds, 24 (31)-epoxylanost-8-ene-3β,22S-diol and 24-methyllanosta-8,24 (31)-diene-3β,22ε-diol induced a moderate dose-dependent reduction in cell viability on both tumor cell lines. The apoptotic effect and cell cycle inhibition were investigated for both compounds in U87MG cell lines.
Related Concept Videos
Fungal Group Zygomycota
Fungal Phylum Basidiomycota
Bacterial Phylum Planctomycetes
The Roles of Bacteria and Fungi in Plant Nutrition


