Related Experiment Video

Updated: Aug 7, 2025

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

9.8K

Monocyte chemokine receptors as therapeutic targets in cardiovascular diseases

Danielle Borges Germano1, Steffany Bernardo Oliveira1, André Luis Lacerda Bachi1

  • 1Post Graduation Program in Health Sciences, Santo Amaro University, Sao Paulo, Brazil.

Immunology Letters
|March 9, 2023
PubMed

Insights

Blocking chemokine receptors shows promise for treating cardiovascular diseases like atherosclerosis by preventing cell migration. However, clinical application faces challenges that require further research for successful therapeutic strategies.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pharmacology

Background:

  • Chemokine receptors play key roles in cardiovascular disease processes, including monocyte recruitment and angiogenesis.
  • Experimental data suggest targeting chemokine receptors could treat atherosclerosis, but clinical evidence is limited.

Purpose of the Study:

  • To review promising results of chemokine receptor blockade for cardiovascular disease treatment.
  • To discuss challenges hindering the clinical use of these therapeutic strategies.

Main Methods:

  • Literature review of experimental and clinical studies on chemokine receptor blockade in cardiovascular diseases.
  • Analysis of therapeutic potential and clinical translation barriers.

Main Results:

  • Chemokine receptor blockade demonstrates potential in preclinical models of atherosclerosis.
  • Significant hurdles remain in translating these findings into effective clinical treatments.

Conclusions:

  • Targeting chemokine receptors is a promising therapeutic avenue for cardiovascular diseases.
  • Overcoming clinical challenges is crucial for the successful implementation of these strategies.

Keywords:
AtherosclerosisChemokine ligandsMonocytesTherapeutic target

More Related Videos

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions09:41

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

13.4K
Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro09:16

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

7.1K

Related Concept Videos

Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.1K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.6K