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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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The QuinteT Recruitment Intervention and its Role in Oncology Randomised Controlled Trials.

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Advances in Skin Brachytherapy: Cosmesis and Function Preservation.

A Rembielak1, G Mansy2, E A Barnes3

  • 1Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|March 9, 2023
PubMed
Summary

Skin brachytherapy is an effective treatment for non-melanoma skin cancers, offering precise radiation delivery and reduced toxicity. This method is ideal for preserving function and appearance, particularly for head and neck cancers.

Keywords:
3D printed mouldselectronic brachytherapyimage-guided superficial brachytherapyskin brachytherapy

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Area of Science:

  • Oncology
  • Radiotherapy

Background:

  • Non-melanoma skin cancers require effective treatment options.
  • External beam radiotherapy can have limitations in dose conformity and toxicity.

Purpose of the Study:

  • To highlight skin brachytherapy as a beneficial treatment for non-melanoma skin cancers.
  • To discuss the advantages of skin brachytherapy over traditional radiotherapy.

Main Methods:

  • Review of skin brachytherapy principles and applications.
  • Comparison of dose distribution and treatment volume with external beam radiotherapy.

Main Results:

  • Skin brachytherapy provides superior dose conformity and rapid dose fall-off, minimizing radiotherapy-related toxicity.
  • Smaller treatment volumes facilitate hypofractionation, reducing patient visits.
  • Excellent preservation of function and cosmesis, especially for head and neck malignancies.

Conclusions:

  • Skin brachytherapy is an excellent alternative for non-melanoma skin cancers, offering improved outcomes and patient convenience.
  • Emerging advances like electronic brachytherapy and 3D printed moulds are enhancing treatment possibilities.