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Effects of intravenous emulsified perfluorochemicals on hepatic cytochrome P-450
R Huang1, D Y Cooper, H A Sloviter
1Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Abstract:
Intravenous infusion of emulsified perfluorodecalin in rats caused a large increase in hepatic cytochrome P-450 concentration which persisted for many weeks. In contrast, hepatic cytochrome P-450 concentration was not changed significantly after infusion of perfluorotributylamine, but subsequent administration of phenobarbital caused the usual increase of cytochrome P-450. The cytochrome P-450 activity for demethylation of benzphetamine was decreased slightly after perfluorodecalin but was unchanged after perfluorotributylamine. The difference in the effects of these perfluorochemicals on hepatic cytochrome P-450 may be related to the difference in the time these compounds are retained in the liver.
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