Related Experiment Video
Updated: Aug 7, 2025
07:13
Orienteering as a Tool for Cognitive Research: An Implementation Guide
Published on: November 29, 2024
852
Association between exercise habit changes and incident dementia after ischemic stroke
Dae Young Cheon1, Kyung do Han2, Chi-Hun Kim3
1Division of Cardiology, Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hwaseong, South Korea.
Scientific Reports
|March 9, 2023
Summary
Starting or maintaining exercise after ischemic stroke significantly lowers dementia risk. Regular physical activity, both before and after stroke, is key for cognitive health and reducing dementia incidence.
Area of Science:
- Neurology
- Public Health
- Gerontology
Background:
- Ischemic stroke is a leading cause of disability and cognitive decline.
- Dementia is a significant post-stroke complication, increasing healthcare burden.
- Understanding modifiable risk factors like exercise is crucial for stroke recovery and prevention.
Purpose of the Study:
- To examine the association between changes in exercise habits and the risk of developing dementia after ischemic stroke.
- To identify specific exercise patterns (initiation, maintenance, cessation) that influence post-stroke dementia risk.
- To explore the impact of exercise on dementia risk across different age groups and physical activity levels.
Main Methods:
- Retrospective cohort study using the Korean National Health Insurance Services Database.
- Inclusion of 223,426 patients diagnosed with ischemic stroke (2010-2016) with two health checkups.
- Categorization of participants into persistent non-exercisers, new exercisers, exercise dropouts, and exercise maintainers based on habit changes.
- Multivariate Cox proportional hazard models to assess dementia risk, adjusting for covariates.
Main Results:
- A total of 22,554 dementia cases (10.09%) were observed during a median follow-up of 4.02 years.
- Exercise dropouts, new exercisers, and exercise maintainers showed significantly lower dementia risk compared to persistent non-exercisers.
- The protective effect of exercise habit changes was more pronounced in the 40-65 years age group.
- Post-stroke energy expenditure ≥1000 MET-min/wk was associated with reduced dementia risk, irrespective of pre-stroke activity.
Conclusions:
- Initiating or continuing moderate-to-vigorous exercise post-ischemic stroke is linked to a reduced risk of dementia.
- Pre-stroke regular physical activity also contributes to a lower incidence of dementia.
- Promoting exercise interventions for ambulatory stroke patients may be an effective strategy to mitigate future dementia risk.
More Related Videos
Related Concept Videos
01:30Dementia
150
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
150
01:20Exercise and Cardiovascular Response
894
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
894
01:27Regulation of Stroke Volume
3.4K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.4K
01:17Ischemic Heart Disease: Overview
1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K
01:26Exercise Stress Test
329
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
329
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
1.2K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
1.2K