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Use of Continuous Intravenous Anakinra Infusion in Multisystem Inflammatory Syndrome in Children

Abdulaziz Alolayan1, Abdullah S Aldamegh2, Azzah Alkhayrat1

  • 1Pharmacy Department, Prince Sultan Military Medical City, Saudi Arabia.

Case Reports in Critical Care
|March 10, 2023
PubMed

Insights

Anakinra, an IL-1 receptor antagonist, offers a potential lifesaving treatment for children with critical COVID-19 and multisystem inflammatory syndrome (MIS-C). This case study highlights successful intravenous anakinra therapy in managing cytokine storm complications.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Immunology

Background:

  • Coronavirus disease (COVID-19) is a global pandemic with significant mortality.
  • Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of COVID-19, often involving a cytokine storm.
  • Anakinra, an interleukin-1 (IL-1) receptor antagonist, is used to mitigate exaggerated inflammatory responses.

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