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Faster bi-stable visual switching in psychosis
Kyle W Killebrew1, Hannah R Moser1, Andrea N Grant2
1Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN.
Medrxiv : the Preprint Server for Health Sciences
|March 10, 2023
Summary
People with psychotic psychopathology (PwPP) and their relatives exhibit faster bi-stable perception switch rates, suggesting disrupted neural suppression. This finding links genetic liability for psychosis to altered visual perception.
Area of Science:
- Neuroscience
- Psychology
- Psychiatry
Background:
- Bi-stable stimuli present two competing perceptions, likely due to neural population suppression.
- Abnormal visual perception in people with psychotic psychopathology (PwPP) may stem from impaired neural suppression.
- The impact of psychotic psychopathology on bi-stable perception remains unclear.
Approach:
- Examined bi-stable perception using a structure-from-motion (SFM) rotating cylinder illusion in PwPP, relatives, and controls.
- Utilized a 'real switch' task to ensure adequate participant performance.
- Measured neurochemical concentrations (glutamate, glutamine, GABA) in visual cortex via 7 tesla MR spectroscopy.
Key Points:
- PwPP and their relatives demonstrated significantly faster bi-stable switch rates compared to healthy controls.
- Faster switch rates correlated with higher psychiatric symptom severity across all participants.
- No significant correlation was found between neurochemical concentrations and SFM switch rates.
Conclusions:
- Results suggest reduced neural suppression during SFM perception in PwPP.
- Genetic liability for psychosis is associated with disruptions in bi-stable perception.
- Altered neural suppression may underlie visual perception deficits in individuals with psychotic psychopathology.
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