Jove
Visualize
Contact Us

Related Experiment Videos

Milan Mohammad1,2, Zakaria Alaoui-Ismaili1, Michael Dan Arvig2,3

  • 1Biomedicinsk Institut, Københavns Universitet.

Ugeskrift for Laeger
|March 10, 2023
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unravelling emergency department triage in everyday practice: An ethnographic study of underlying mechanisms across three Danish emergency departments.

BMC emergency medicine·2026
Same author

Effects of tocilizumab on neutrophil gelatinase-associated lipocalin following out-of-hospital cardiac arrest, and its prognostic value.

Resuscitation plus·2026
Same author

Implementing Digital Respiratory Technologies for People With Respiratory Conditions: Scoping Review.

Journal of medical Internet research·2026
Same author

[Carpal tunnel syndrome].

Ugeskrift for laeger·2026
Same author

Alveolar-capillary reserve in COPD assessed by the pulmonary diffusing capacity response to an upright-to-supine postural change.

Experimental physiology·2026
Same author

Self-regulating the use of large language models in clinical practice: a risk-stratified approach.

BMJ health & care informatics·2026
Same journal

[Mosaicism as a cause of Cowden syndrome].

Ugeskrift for laeger·2026
Same journal

[Thyrotoxic crisis with cardiogenic shock].

Ugeskrift for laeger·2026
Same journal

[Mindfulness-based cognitive therapy in the treatment of depression].

Ugeskrift for laeger·2026
Same journal

[Fitness].

Ugeskrift for laeger·2026
Same journal

[Risk of developing cataract related to fluoroscopy].

Ugeskrift for laeger·2026
Same journal

[Obturator hernia with small bowel ileus presenting as hip pain in an elderly woman].

Ugeskrift for laeger·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Intense exercise can cause rhabdomyolysis, leading to elevated liver enzymes like AST and ALT. These enzyme elevations often indicate muscle damage, not liver injury, preventing unnecessary tests.

Area of Science:

  • Sports Medicine
  • Biochemistry
  • Clinical Pathology

Background:

  • Rhabdomyolysis is a condition involving skeletal muscle breakdown.
  • Elevated liver enzymes, aspartate transaminase (AST) and alanine transaminase (ALT), can be observed in rhabdomyolysis.
  • Distinguishing muscle-derived enzyme elevation from true liver damage is crucial for accurate diagnosis and treatment.

Observation:

  • A case report details rhabdomyolysis following strenuous physical activity.
  • Initial laboratory tests revealed significantly elevated creatine kinase, consistent with muscle damage.
  • Aspartate transaminase (AST) and alanine transaminase (ALT) levels were also markedly increased, initially suggesting liver injury.

Findings:

  • The elevated AST and ALT levels were primarily attributed to skeletal muscle damage, a common finding in rhabdomyolysis.

Related Experiment Videos

  • Specific liver function markers, including international normalised ratio (INR) and ϒ-glutamyl transferase (GGT), remained within normal limits.
  • This pattern indicates that AST and ALT elevations in this context are more indicative of muscle breakdown than hepatocellular damage.

    • Implications:

    • Understanding the source of elevated AST and ALT in rhabdomyolysis is critical for avoiding misdiagnosis of liver disease.
    • This knowledge can guide clinicians to avoid unnecessary diagnostic procedures and liver-specific treatments.
    • Accurate interpretation of liver enzymes in the setting of muscle injury can lead to more efficient patient management.