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Efficacy of Bifidobacterium longum alone or in multi-strain probiotic formulations during early life and beyond

Susan Mills1, Bo Yang2, Graeme J Smith3

  • 1APC Microbiome Ireland, University College Cork, Cork, Ireland.

Gut Microbes
|March 10, 2023
PubMed

Insights

Bifidobacterium longum is a key gut bacterium that impacts health from infancy through adulthood. Its beneficial properties, including producing bioactive molecules, support immune and brain functions, warranting further clinical research.

Area of Science:

  • Microbiology
  • Human Health
  • Gut Microbiome

Background:

  • Bifidobacterium longum is the most abundant species colonizing the neonatal gut.
  • Its abundance decreases with age and is reduced in various diseases.
  • B. longum plays a crucial role in maintaining human health throughout the lifespan.

Approach:

  • This review synthesizes biological and clinical evidence on Bifidobacterium longum.
  • It explores the mechanisms behind B. longum's beneficial effects.
  • The review examines the impact of B. longum across different human conditions.

Key Points:

  • B. longum produces bioactive molecules like short-chain fatty acids, polysaccharides, and serine protease inhibitors.
  • This species influences immune responses in the lungs and skin.
  • B. longum affects brain activity, demonstrating systemic health benefits.

Conclusions:

  • Bifidobacterium longum has significant biological and clinical impacts on human health.
  • Evidence supports B. longum's potential in preventing and treating diseases.
  • Further research and clinical trials are recommended to explore its therapeutic applications.

Keywords:
BifidobacteriumBifidobacterium longum ssp. infantisBifidobacterium longum ssp. longumCardiovascular diseaseCognitive impairmentGut microbiotaHealthImmunityNecrotizing enterocolitisNeonateProbiotic

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