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Efficacy of endoscopic porcine small intestinal submucosa graft myringoplasty: a retrospective comparative study
Li Jin1, Xueying Pan1, Tuanfang Yin1
1Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Background:
The surgical outcomes following tympanic membrane (TM) repair are affected by many factors.
Objectives:
To evaluate the efficacy of endoscopic porcine small intestine submucosa graft (PSISG) myringoplasty by comparing with endoscopic myringoplasty with temporal fascia (TF) and perichondrium (PC).
Methods:
We conducted a retrospective comparative study that a total of 98 patients with TM perforations were included. The patients underwent endoscopic myringoplasty using PSISG, TF or PC as the graft. The closure rate, hearing outcomes, operative time and complications in three groups were compared.
Results:
At 3 months postoperatively, the closure rate were 85.2% (23/27), 92.1% (35/38) and 87.9% (29/33) in the PSISG, TF and PC groups respectively (p = .667); Hearing improved after surgery in three groups (p < .001), and showed no significant difference among the three groups. The mean operative time of the PSISG group was shorter than autologous TF (p < .001) and PC groups (p < .001) in this study; No operative or postoperative complications were found among the three groups.
Conclusion:
Compare to autologous temporal fascia or perichondrium, the PSISG appears to be an effective and safe material for TM perforations closure. Endoscopic PSISG myringoplasty may be an alternative technique for repairing TM perforations, especially for revision cases.
Insights
Porcine small intestine submucosa graft (PSISG) myringoplasty is effective for tympanic membrane repair, showing comparable closure rates and hearing outcomes to traditional grafts. This endoscopic technique offers a safe alternative, particularly for revision surgeries.
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Surgical Innovation
Background:
- Tympanic membrane (TM) perforations are common, and surgical repair outcomes depend on various factors.
- Traditional grafting materials include temporal fascia (TF) and perichondrium (PC).
Purpose of the Study:
- To evaluate the efficacy of endoscopic porcine small intestine submucosa graft (PSISG) myringoplasty.
- To compare PSISG myringoplasty with traditional endoscopic myringoplasty using TF and PC.
Main Methods:
- A retrospective comparative study included 98 patients with TM perforations.
- Patients underwent endoscopic myringoplasty using PSISG, TF, or PC grafts.
- Outcomes measured included closure rate, hearing improvement, operative time, and complications.
Main Results:
- At 3 months, closure rates were 85.2% (PSISG), 92.1% (TF), and 87.9% (PC), with no significant difference (p=0.667).
- Hearing improved significantly in all groups (p<0.001) with no intergroup differences.
- PSISG group had a shorter operative time (p<0.001) and no complications were observed.
Conclusions:
- PSISG is an effective and safe graft material for TM perforations.
- Endoscopic PSISG myringoplasty presents a viable alternative for TM repair, especially in revision cases.
