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Occupation and five cancers: a case-control study using death certificates.

C Magnani¹, D Coggon, C Osmond

¹MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK.

British Journal of Industrial Medicine

|November 1, 1987

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This study investigated cancer mortality in men in English chemical manufacturing areas. Increased risks for brain cancer were linked to meat/fish production and oil refining, and melanoma risk was noted in refinery workers.

Area of Science:

Occupational Epidemiology
Environmental Health
Cancer Research

Background:

Cancer mortality rates vary geographically and may be influenced by local industries.
Chemical manufacturing centers present unique opportunities to study occupational exposures and health outcomes.
National statistics may lack the granularity to identify localized occupational risks.

Purpose of the Study:

To examine mortality risks for five specific cancers (oesophagus, pancreas, cutaneous melanoma, kidney, brain) in men residing in English chemical industry hubs.
To investigate potential associations between occupational exposures in specific industries and cancer mortality.
To supplement national occupational mortality data with localized, statistically powered analyses.

Main Methods:

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A case-control study design was employed, matching cancer cases with controls who died from other causes.

Data from 20 years of mortality records were analyzed for men in three English counties with significant chemical manufacturing.

Occupations and industries were coded from death certificates, and risk estimates were calculated for job categories.

Main Results:

Elevated brain cancer risk was associated with meat and fish product manufacturing (Relative Risk [RR] = 9.7) and mineral oil refining (RR = 2.9).
A notable cluster of cutaneous melanoma deaths (RR = 16.0) was observed among mineral oil refinery workers.
A job-exposure matrix analysis did not reveal further strong disease associations.

Conclusions:

Local occupational mortality studies can provide valuable insights beyond national statistics.
Specific industries, such as meat/fish processing and mineral oil refining, may pose elevated risks for certain cancers.
Further investigation into occupational exposures in these industries is warranted to understand cancer risks.