Cognitive function after carotid endarterectomy in asymptomatic patients
Edward C Oh1, Natalie D Sridharan2, Efthymios D Avgerinos3,4
1Division of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA - ohec@upmc.edu.
The Journal of Cardiovascular Surgery
|March 10, 2023
Summary
Carotid endarterectomy (CEA) may help slow neurocognitive decline in patients with asymptomatic carotid stenosis. However, inconsistent study designs and cognitive tests limit definitive conclusions, necessitating further research.
Area of Science:
- Neurology
- Vascular Surgery
Background:
- Asymptomatic carotid stenosis is linked to neurocognitive decline.
- The impact of carotid endarterectomy (CEA) on cognitive function remains unclear.
- Existing research shows heterogeneity in study designs and cognitive assessments.
Purpose of the Study:
- To review current evidence on cognitive function in asymptomatic carotid stenosis patients undergoing CEA.
- To evaluate the potential benefits of CEA in mitigating neurocognitive decline.
- To identify gaps in research regarding the relationship between carotid stenosis, CEA, and cognitive outcomes.
Main Methods:
- Literature review of preoperative and postoperative cognitive function studies.
- Analysis of studies involving patients with asymptomatic carotid stenosis undergoing CEA.
- Assessment of cognitive function tests and study design standardization.
Main Results:
- Evidence suggests CEA may reverse or slow neurocognitive decline.
- Definitive conclusions are hindered by study heterogeneity and lack of standardized testing.
- A direct etiological role of asymptomatic carotid stenosis in cognitive decline is not established.
Conclusions:
- Further research is required to clarify the benefits of CEA for cognitive function in asymptomatic carotid stenosis.
- Standardization of cognitive assessment and study design is crucial for future research.
- Understanding the relationship between carotid stenosis, CEA, and cognitive health is essential.
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