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Published on: September 10, 2017
License to kill: Retinoic acid programs T cells for tissue residency
Maximilian Heeg1, Ananda W Goldrath1
1Department of Molecular Biology, University of California, San Diego , La Jolla, CA, USA.
Abstract:
In this issue of JEM, Qiu et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20210923) show that retinoic acid signaling during priming in the mesenteric lymph node licenses CD8+ T cells to develop into small intestinal tissue-resident memory cells, a finding that provides key insights into tissue-specific vaccination strategies.
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