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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Carbohydrate Metabolism01:36

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Updated: Aug 7, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

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Sex differences in type 2 diabetes.

Alexandra Kautzky-Willer1,2, Michael Leutner3, Jürgen Harreiter3

  • 1Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria. alexandra.kautzky-willer@meduniwien.ac.at.

Diabetologia
|March 10, 2023
PubMed
Summary

Type 2 diabetes mellitus affects more men, but women face greater risks and complications, including cardiovascular disease. Sex-specific prevention and treatment strategies are needed for effective type 2 diabetes management.

Keywords:
Cardiovascular mortalityGenderMacrovascular complicationsMicrovascular complicationsReviewRisk factorsSexTherapyType 2 diabetes

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Area of Science:

  • Endocrinology
  • Cardiology
  • Public Health

Background:

  • Type 2 diabetes mellitus (T2DM) prevalence is rising globally in both sexes.
  • Men are typically diagnosed younger with lower body fat mass compared to women.
  • Women with T2DM exhibit a higher burden of risk factors, including obesity and psychosocial stress.

Purpose of the Study:

  • To summarize sex-specific clinical features and differences in T2DM risk factors, screening, diagnosis, complications, and treatment between men and women.
  • To highlight the need for sex-specific and gender-sensitive prevention and management strategies.

Main Methods:

  • This study is a narrative review.
  • It synthesizes existing literature on sex differences in T2DM.

Main Results:

  • Women experience unique risk factors like gestational diabetes and menopause, increasing cardiometabolic risk.
  • Women with T2DM have a higher relative risk of cardiovascular disease (CVD) and mortality.
  • Young women with T2DM are less likely to receive guideline-recommended treatment and CVD risk reduction.

Conclusions:

  • Current medical guidelines lack sex-specific recommendations for T2DM prevention and management.
  • Further research into sex differences and underlying mechanisms is crucial.
  • Intensified screening and early risk management are essential for both sexes to combat T2DM and associated CVDs.