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Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
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β-Sheet Assembly Translates Conservative Single-Site Mutation into a Perturbation in Macroscopic Structure

Wenbo Zhang1, Mingwei Liu1, Yang Wang1

  • 1State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, P. R. China.

Nano Letters
|March 10, 2023
PubMed
Summary

Single amino acid changes in synthetic peptides significantly alter their macroscale assembly and properties. This study reveals how small sequence variations amplify to affect protein quaternary structure and fibril formation.

Keywords:
peptide assemblyprotein foldingprotein phase transitionsscanning tunneling microscopysingle-site mutation

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